Kinetics of 9-aminoacridine block of single Na channels.
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چکیده
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Kinetics of 9-aminoacridine block of single Na channels
The kinetics of 9-aminoacridine (9-AA) block of single Na channels in neuroblastoma N1E-115 cells were studied using the gigohm seal, patch clamp technique, under the condition in which the Na current inactivation had been eliminated by treatment with N-bromoacetamide (NBA). Following NBA treatment, the current flowing through individual Na channels was manifested by square-wave open events las...
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Background. Cellular signaling involves a sequence of events from ligand binding to membrane receptors through transcription factors activation and the induction of mRNA expression. The transcriptional-regulatory system plays a pivotal role in the control of gene expression. A novel computational approach to the study of gene regulation circuits is presented here. Methodology. Based on the conc...
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ژورنال
عنوان ژورنال: Journal of General Physiology
سال: 1984
ISSN: 0022-1295,1540-7748
DOI: 10.1085/jgp.84.3.361